Page last updated: Thursday, June 18, 2009
Adolescent binge drinking may compromise the brain’s white matter, necessary for information relay
Researchers know that the integrity of the brain’s white matter is compromised in adult alcoholics, but it is unclear when during the course of drinking white matter abnormalities become apparent. A study of adolescent binge drinkers has found that even relatively infrequent exposure to large doses of alcohol during youth may compromise white matter fiber coherence.

Susan F. Tapert, associate professor of psychiatry at the University of California, San Diego and director of Substance Abuse/Mental Illness in the VA San Diego Healthcare System states “Because the brain is still developing during adolescence, there has been concern that it may be more vulnerable to the effects of neurotoxins, such as high doses of alcohol,” . Animal studies have suggested this is accurate.

Duncan Clark, associate professor of psychiatry at the University of Pittsburgh Medical Center explains “’White matter’ refers to brain areas that appear light in color due to being primarily lipids...White matter is composed of bundles of myelinated axons connecting grey matter areas of the brain, and has been shown to continue to develop throughout adolescence. These systematic changes in white matter organisation reflect not only maturation of interconnections but continued maturation of the brain as a whole.”

“White matter, and its integrity, are essential to the efficient relay of information within the brain,” said Tapert. “Indicators of white matter integrity are linked to performance on a range of cognitive tests, including measures of reading, copying complex figures, and speeded coding of information. Abnormalities in white matter health could relate to compromised ability to consider multiple sources of information when making decisions, and to emotional functioning.”

Tapert and her colleagues used diffusion tensor imaging – an MRI technique sensitive to the random movement of water in cells of a target tissue – to examine fractional anisotropy, a measure of directional coherence of white matter tracts, among 28 teens. Of the 28, 14 (12 males, 2 females) had and 14 (12 males, 2 females) did not have histories of binge drinking. No participants had a history of an alcohol use disorder; drinkers were matched to non-drinkers on age, gender and education.

The authors found that adolescents with histories of binge drinking episodes have lower coherence of white matter fibres, suggesting poorer white matter health, in a variety of brain regions. This was unexpected, as the drinkers did not meet criteria for alcohol abuse or dependence.”

Clarke commented that “These findings add to a growing literature indicating that adolescent alcohol involvement is associated with specific brain characteristics,...One of the advantages of this study was that the adolescents with binge drinking did not have major mental disorders. Adolescents with alcohol-use disorders often have other problems. This suggests that the observed brain characteristics may be associated with alcohol involvement specifically rather than other complications.”

Tapert concluded that drinking to the point of being drunk or experiencing hangover symptoms may be detrimental to the adolescent brain. However, long-term studies following adolescents over time are essential to clarify the extent to which alcohol causes these brain abnormalities.

Clark stated “These findings indicate that adolescents who engage in binge drinking show low levels of brain organisation,” he said. “This characteristic could be a risk factor for accelerated alcohol use or an effect of alcohol. We need to know more about how alcohol influences adolescent brain development, [given] that alcohol may disrupt brain development.”

Source: Results will be published in the July issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.

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