The impact of moderate wine consumption on the risk of prostate cancer (PCa) was investigated in a meta analysis, with a focus on the differential effect of moderate consumption of red versus white wine.
A systematic search of research databases was conducted looking for case-control and cohort studies that assessed the risk of PCa due to red, white, or any wine using multivariable logistic regression analysis. A total of 930 abstracts and titles were initially identified. After removal of duplicates, reviews, and conference abstracts, 83 full-text original articles were screened. Seventeen studies (611,169 subjects) were included for final evaluation and fulfilled the inclusion criteria.
The researchers performed a formal meta-analysis for the risk of PCa according to moderate wine and wine type consumption (white or red).
In the case of moderate wine consumption: the pooled risk ratio (RR) for the risk of PCa was 0.98 (95% CI 0.92-1.05, p=0.57) in the multivariable analysis. Moderate white wine consumption increased the risk of PCa with a pooled RR of 1.26 (95% CI 1.10-1.43, p=0.001) in the multi-variable analysis, but moderate red wine consumption had a protective role reducing the risk by 12% (RR 0.88, 95% CI 0.78-0.999, p=0.047).
In this meta-analysis, moderate wine consumption did not impact the risk of PCa. Interestingly, regarding the type of wine, moderate consumption of white wine increased the risk of PCa, whereas moderate consumption of red wine had a protective effect. Further analyses are needed to assess the differential molecular effect of white and red wine conferring their impact on PCa risk, the authors argue.
Source: The impact of moderate wine consumption on the risk of developing prostate cancer. Vartolomei MD, Kimura S, Ferro M, Foerster B, Abufaraj M, Briganti A, Karakiewicz PI, Shariat SF. Clin Epidemiol. 2018 Apr 17;10:431-444.