Inverse association of light-to-moderate alcohol drinking with cardio metabolic index in men with diabetes mellitus Cardio metabolic index (CMI), calculated as the product of waist-to-height ratio and triglyceridesto- HDL cholesterol ratio, has been proposed as a discriminator of diabetes and has been reported to be associated with progression of atherosclerosis. A study aimed to determine the relationship between alcohol drinking and CMI in men with diabetes.
1411 Japanese male workers aged 35 - 65 years with diabetes mellitus were included in the study. They were grouped based on average daily alcohol consumption into 4 categories of alcohol drinking (non-drinkers; light drinkers, < 22g; moderate drinkers, ≥ 22g and < 44g; heavy drinkers, ≥ 44g). CMI and variables comprising CMI were compared in the non-drinker and each of the drinker groups. Age, habits of smoking and regular exercise, and a present history of medication therapy for diabetes were adjusted in each analysis.
Log-transformed CMI was significantly lower in light and moderate drinkers than in nondrinkers. Waist-to-height ratio was significantly lower in moderate drinkers than in non-drinkers, while triglycerides was significantly higher in heavy drinkers than in non-drinkers. HDL (good) cholesterol tended to be higher with an increase of alcohol consumption. Compared to non-drinkers, the odds ratios for high CMI were 0.53 (0.36-0.78) in light drinkers, 0.61 (0.46-0.80) in moderate drinkers, and 0.74 (0.55-1.00) in heavy drinkers.
In men with diabetes, CMI is lower in light-tomoderate drinkers than in non-drinkers, and this results mainly from a positive association between alcohol drinking and HDL (good) cholesterol.
Source: Inverse association of light-to-moderate alcohol drinking with cardio metabolic index in men with diabetes mellitus. Wakabayashi I. Diabetes Metab Syndr. 2018 Nov;12(6):1013-1017. .