Dementia and cognitive decline have become worldwide public health problems, and it was recently reported that life-style related diseases and obesity are key risk factors in dementia.
Iso-α-acids, hop-derived bitter components of beer, have been reported to have various physiological functions via activation of peroxisome proliferator-activated receptor γ. In a paper published in Science Reports, the authors demonstrate that daily intake of iso-α-acids suppresses inflammations in the hippocampus and improves cognitive decline induced by high fat diet (HFD).
Body weight, epididymal fat weight, and plasma triglyceride levels were increased in HFD-fed mice, and significantly decreased in iso-α-acids supplemented HFD-fed mice. HFD feeding enhances the production of inflammatory cytokines and chemokines, such as TNF-α, which was significantly suppressed by iso-α-acids administration. HFD-induced neuroinflammation caused lipid peroxidation, neuronal loss, and atrophy in hippocampus, and those were not observed in iso-α-acids-treated mice. Furthermore, iso-α-acids intake significantly improved cognitive decline induced by HFD-feeding.
Iso-α-acids are food derived components that suppress both lipid accumulation and brain inflammation, thus iso-α-acids might be beneficial to a reduction in risk of dementia that is increased by obesity and lifestyle-related diseases, the authors state.
Source: Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline. Ayabe T, Ohya R, Kondo K, Ano Y Sci Rep. 2018 Mar 19;8(1):4760. doi. org/10.1038/s41598-018-23213-9.